The University of Chicago Header Logo

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following items that are connected to Froelich, Christopher
Item TypeName
Concept Adenoviridae
Concept Antigen-Antibody Complex
Concept Antigens, Neoplasm
Concept Antibiotics, Antineoplastic
Concept Antibody-Dependent Cell Cytotoxicity
Concept Arthritis, Experimental
Concept Anemia, Pernicious
Concept Calcimycin
Concept Abscess
Concept Agammaglobulinemia
Concept alpha-Macroglobulins
Concept Binding Sites, Antibody
Concept Breast Neoplasms
Concept Amino Acid Sequence
Concept Adenosine Triphosphate
Concept Antigens, Differentiation
Concept Antineoplastic Agents
Concept Antithrombin III
Concept Carboxypeptidases
Concept Cell Fractionation
Concept Animals
Concept Quaternary Ammonium Compounds
Concept Chondrosarcoma
Concept Epitopes
Concept Antibodies, Anti-Idiotypic
Concept Antibodies, Monoclonal
Concept Antigens, Differentiation, T-Lymphocyte
Concept Arthritis, Rheumatoid
Concept Cytoplasmic Granules
Concept Antigens, Differentiation, B-Lymphocyte
Concept Antilymphocyte Serum
Concept B-Lymphocytes
Concept Base Sequence
Concept Cell Nucleus
Concept Aspirin
Concept Autoantigens
Concept DNA Damage
Concept Chondroitin Sulfates
Concept Carcinoma, Renal Cell
Concept Autoantibodies
Concept Binding Sites
Concept beta-Endorphin
Concept Bicarbonates
Concept Brucella
Concept Cattle
Concept Cell Membrane
Concept Cell Separation
Concept Chromatography, Gel
Concept Chromium Radioisotopes
Concept Clone Cells
Concept Cell Transformation, Viral
Concept Cell-Free System
Concept Cholic Acids
Concept Cardiolipins
Concept Cartilage, Articular
Concept Cell Adhesion
Concept Colonic Neoplasms
Concept Chromium
Concept Colicins
Concept Cholesterol
Concept Clathrin
Concept Collagen
Concept Cytosol
Concept Culture Media
Concept Immunoglobulin M
Concept Cysteine Endopeptidases
Concept Cytochrome c Group
Concept Cytoplasm
Concept Detergents
Concept Injections, Intraperitoneal
Concept Interleukin-2
Concept Cytomegalovirus Infections
Concept Cytoskeleton
Concept Cytotoxicity, Immunologic
Concept DNA Repair
Concept Cathepsins
Concept Cytotoxicity Tests, Immunologic
Concept Cytotoxins
Concept Endorphins
Concept Immunoglobulin A
Concept Immunoglobulin Fc Fragments
Concept Etoposide
Concept Extracellular Space
Concept Cobalt
Concept Cocaine
Concept Dextrans
Concept Cytomegalovirus
Concept Melitten
Concept Infant, Newborn
Concept Egtazic Acid
Concept Mice, Inbred C3H
Concept Models, Chemical
Concept Fluorescence
Concept Myasthenia Gravis
Concept Nasal Septum
Concept Fibronectins
Concept Ions
Concept Killer Cells, Natural
Concept Graft Rejection
Concept Hemolysis
Concept DNA Replication
Concept Dose-Response Relationship, Drug
Concept Immune Sera
Concept Leukemia, Experimental
Concept Liposomes
Concept Immune Tolerance
Concept Infectious Mononucleosis
Concept Enzyme-Linked Immunosorbent Assay
Concept Epithelium
Concept Herpesvirus 4, Human
Concept Flow Cytometry
Concept Fluorescent Antibody Technique
Concept Immunity, Cellular
Concept Inflammation
Concept Immunodiffusion
Concept Genes, MHC Class I
Concept Leukocytes, Mononuclear
Concept Light
Concept Macrophages
Concept Lymphocytic Choriomeningitis
Concept Intracellular Fluid
Concept Membrane Glycoproteins
Concept Lymphocyte Culture Test, Mixed
Concept Mice, Inbred Strains
Concept Models, Molecular
Concept Phospholipids
Concept Lymphocytic choriomeningitis virus
Concept Naphthoquinones
Concept Mice, Transgenic
Concept Extracellular Matrix
Concept Immunohistochemistry
Concept Molecular Sequence Data
Concept Mycobacterium tuberculosis
Concept Necrosis
Concept Mice, Inbred BALB C
Concept Mice, Inbred C57BL
Concept Mitogens
Concept Mycobacterium
Concept Cricetinae
Concept Heat-Shock Proteins
Concept HeLa Cells
Concept Hemolysin Proteins
Concept Hepatitis
Concept Penicillamine
Concept Neutrophils
Concept Laminin
Concept Phagocytosis
Concept Lipid Bilayers
Concept Lymphokines
Concept Peptide Hydrolases
Concept Membrane Lipids
Concept Endopeptidases
Concept Phytohemagglutinins
Concept Mouth
Concept Myeloma Proteins
Concept Naloxone
Concept Osteogenesis
Concept Parenteral Nutrition
Concept Tetracycline
Concept Prednisone
Concept Prostatic Neoplasms
Concept Poloxalene
Concept Protein Conformation
Concept Protease Inhibitors
Concept Gamma Rays
Concept Idoxuridine
Concept Immunoglobulin G
Concept Rats, Inbred F344
Concept Receptors, Fc
Concept Recurrence
Concept Regression Analysis
Concept Rabbits
Concept Rosette Formation
Concept Rubidium
Concept Trypsin Inhibitors
Concept Pyruvates
Concept Receptors, Immunologic
Concept Virion
Concept Vitamin B 12
Concept Interferon-gamma
Concept Receptors, Transferrin
Concept Ribonucleoproteins
Concept Serpins
Concept Interleukin-6
Concept Salmonella typhimurium
Concept Sensitivity and Specificity
Concept Thrombin
Concept Thymidine
Concept Sheep
Concept Sulfates
Concept Humans
Concept Hypercholesterolemia
Concept Hypoprothrombinemias
Concept Transcription, Genetic
Concept Protein Biosynthesis
Concept Software
Concept Streptolysins
Concept Interferon Type I
Concept Intracellular Membranes
Concept CHO Cells
Concept Sudden Infant Death
Concept Synovial Membrane
Concept Tumor Necrosis Factor-alpha
Concept Sequence Homology, Amino Acid
Concept Receptors, IgG
Concept Dinoprostone
Concept Iodine Radioisotopes
Concept Kidney Glomerulus
Concept Liver Neoplasms, Experimental
Concept Lysosomes
Concept Herpesvirus 1, Human
Concept Complement Membrane Attack Complex
Concept Cell Culture Techniques
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Caspases
Concept Cryoelectron Microscopy
Concept rab5 GTP-Binding Proteins
Concept Tumor Cells, Cultured
Concept Virus Cultivation
Concept NF-kappa B
Concept Receptors, Interleukin-2
Concept Antigens, CD
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept Lymphoma
Concept Microinjections
Concept Mitochondria
Concept Multiple Myeloma
Concept CD4-Positive T-Lymphocytes
Concept Interleukin-8
Concept Culture Media, Conditioned
Concept Gene Expression
Concept Rats, Wistar
Concept Mutagenesis, Site-Directed
Concept T-Lymphocyte Subsets
Concept Protein Structure, Tertiary
Concept Melanoma
Concept Metacarpophalangeal Joint
Concept Microscopy, Electron, Scanning
Concept Microtubules
Concept Lupus Coagulation Inhibitor
Concept Treatment Outcome
Concept Neoplasms, Experimental
Concept Neutralization Tests
Concept Fluorescein-5-isothiocyanate
Concept Annexin A5
Concept Gene Deletion
Concept Mice, Knockout
Concept CD8-Positive T-Lymphocytes
Concept DNA, Complementary
Concept Receptors, Thrombin
Concept Models, Immunological
Concept Caspase 3
Concept Caspase 7
Concept Fas Ligand Protein
Concept Heparan Sulfate Proteoglycans
Concept Mutation, Missense
Concept Unilamellar Liposomes
Concept Lymphocyte Count
Concept Epitopes, T-Lymphocyte
Concept Jurkat Cells
Concept Protein Structure, Secondary
Concept Octoxynol
Concept Receptors, Purinergic P2X7
Concept COS Cells
Concept Microscopy, Confocal
Concept Amino Acid Substitution
Concept Caspase 1
Concept Pyruvic Acid
Concept Interleukin-1beta
Concept Interleukin 1 Receptor Antagonist Protein
Concept RNA, Small Cytoplasmic
Concept Cyclophilins
Concept Plasma
Concept Prostaglandins E
Concept Polyradiculoneuropathy
Concept Precipitin Tests
Concept Chondroitin Sulfate Proteoglycans
Concept Mice
Concept Caspase 8
Concept Fas-Associated Death Domain Protein
Concept Endosomes
Concept Rheumatoid Factor
Concept Saliva
Concept Chymases
Concept DNA Fragmentation
Concept Research Design
Concept Retinal Artery
Concept RNA, Messenger
Concept Lamin Type A
Concept Sodium Chloride
Concept Specimen Handling
Concept Host-Pathogen Interactions
Concept Multiprotein Complexes
Concept Rats
Concept Static Electricity
Concept Trypsin
Concept Spleen
Concept Subcellular Fractions
Concept Vero Cells
Concept Adaptor Proteins, Signal Transducing
Concept T-Lymphocytes, Cytotoxic
Concept Immunoblotting
Concept Blotting, Western
Concept Serine Proteinase Inhibitors
Concept Tubulin
Concept Receptors, Interleukin-1
Concept Receptor, IGF Type 2
Concept Killer Cells, Lymphokine-Activated
Concept Simplexvirus
Concept Herpesvirus 2, Human
Concept Lymphocyte Subsets
Concept HL-60 Cells
Concept GTP-Binding Proteins
Concept Secretory Vesicles
Concept snRNP Core Proteins
Concept Gene Knockdown Techniques
Concept Phosphatidylinositol 3-Kinases
Concept K562 Cells
Concept Inhibitory Concentration 50
Concept Caenorhabditis elegans Proteins
Concept MAP Kinase Signaling System
Concept Isocoumarins
Concept T-Lymphocytes, Regulatory
Concept CASP8 and FADD-Like Apoptosis Regulating Protein
Concept Tryptases
Concept Granzymes
Concept Dynamins
Concept RNA, Small Interfering
Concept Lectins, C-Type
Concept Cytochromes c
Concept Cell Line, Tumor
Concept Pore Forming Cytotoxic Proteins
Concept Caspase 6
Concept Caspase 10
Concept Aggrecans
Concept Perforin
Concept Antibodies, Neutralizing
Concept Antibodies
Concept Antineoplastic Agents, Phytogenic
Concept Antibodies, Antinuclear
Concept Arthritis, Juvenile
Concept Aurintricarboxylic Acid
Concept Binding, Competitive
Concept Calcium
Concept Cell Line
Concept Cell Nucleolus
Concept Cells, Cultured
Concept Chlamydia Infections
Concept Chymotrypsin
Concept Coumarins
Concept Delayed-Action Preparations
Concept Disease Models, Animal
Concept DNA, Single-Stranded
Concept Doxorubicin
Concept Drug Screening Assays, Antitumor
Concept Enkephalin, Methionine
Concept Erythrocytes
Concept Esterases
Concept Fluorescent Dyes
Concept Immunologic Memory
Concept Injections, Subcutaneous
Concept Longitudinal Studies
Concept Lymphocyte Activation
Concept Lymphocytes
Concept Membrane Potentials
Concept Microscopy, Fluorescence
Concept Models, Biological
Concept Monocytes
Concept Nuclear Envelope
Concept Phosphatidylserines
Concept Receptors, Antigen, T-Cell
Concept Receptors, Opioid
Concept Retrospective Studies
Concept Sclerosis
Concept Serine Endopeptidases
Concept Staining and Labeling
Concept Synovial Fluid
Concept T-Lymphocytes
Concept Uveal Neoplasms
Concept Leukemia, T-Cell
Concept HIV-1
Concept Immunophenotyping
Concept Cytokines
Concept Bacteremia
Concept Ribonucleoproteins, Small Nuclear
Concept DNA Primers
Concept Deltaretrovirus
Concept Gelsolin
Concept Macrolides
Concept fas Receptor
Concept U937 Cells
Concept Membrane Microdomains
Concept Fluorescence Resonance Energy Transfer
Concept Vesicular Transport Proteins
Concept Cathepsin A
Concept Proto-Oncogene Proteins c-akt
Concept Membrane Potential, Mitochondrial
Concept Caspase 9
Academic Article ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Academic Article The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.
Academic Article Routine measurement of IgM, IgG, and IgA rheumatoid factors: high sensitivity, specificity, and predictive value for rheumatoid arthritis.
Academic Article New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.
Academic Article Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.
Academic Article An antimicrobial activity of cytolytic T cells mediated by granulysin.
Academic Article Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
Academic Article Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
Academic Article Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
Academic Article Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays.
Academic Article Nuclear targeting of the serine protease granzyme A (fragmentin-1).
Academic Article BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
Academic Article P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins.
Academic Article Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors.
Academic Article Purification and use of granzyme B.
Academic Article Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.
Academic Article Pro-caspase-3 is a major physiologic target of caspase-8.
Academic Article HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas.
Academic Article Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis.
Academic Article Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.
Academic Article Cell death-associated translocation of plasma membrane components induced by CTL.
Academic Article HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.
Academic Article Flow cytometry cannot assess surface binding of perforin to target cells.
Academic Article A distinct pathway of cell-mediated apoptosis initiated by granulysin.
Academic Article Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis.
Academic Article NF-kappaB protects from the lysosomal pathway of cell death.
Academic Article Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.
Academic Article Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules.
Academic Article The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins.
Academic Article Granzyme B-mediated apoptosis--the elephant and the blind men?
Academic Article Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage.
Academic Article Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.
Academic Article SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity.
Academic Article The T cell death knell: immune-mediated tumor death in renal cell carcinoma.
Academic Article A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
Academic Article Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.
Academic Article Human neutrophils lack granzyme A, granzyme B, and perforin.
Academic Article A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
Academic Article Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.
Academic Article Detection of functional cell surface perforin by flow cytometry.
Academic Article Granzyme B translocates across the lipid membrane only in the presence of lytic agents.
Academic Article Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.
Academic Article Granule-associated serine proteases: granzymes might not just be killer proteases.
Academic Article Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.
Academic Article Clinical value of an integrated ELISA system for the detection of 6 autoantibodies (ssDNA, dsDNA, Sm, RNP/Sm, SSA, and SSB).
Academic Article Retinal vein thrombosis in a patient with pernicious anemia and anticardiolipin antibodies.
Academic Article Granzyme A is a proinflammatory protease.
Academic Article Mouse granzyme K has pro-inflammatory potential.
Academic Article Intracellular trafficking of perforin: to thwart a killer.
Academic Article NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.
Academic Article Lysis of human T cell leukemia virus infected T and B lymphoid cells by interleukin 2-activated killer cells.
Academic Article Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice.
Academic Article Perforin activity at membranes leads to invaginations and vesicle formation.
Academic Article Modulation of the autologous mixed lymphocyte reaction by beta-endorphin.
Academic Article Modulation of the tumor cell phenotype by IFN-gamma results in resistance of uveal melanoma cells to granule-mediated lysis by cytotoxic lymphocytes.
Academic Article A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.
Academic Article Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells.
Academic Article Human and mouse granzyme A induce a proinflammatory cytokine response.
Academic Article The effect of beta-endorphin on natural cytotoxicity and antibody dependent cellular cytotoxicity.
Academic Article Natural cytotoxicity in systemic lupus erythematosus: mechanisms of suppression by inhibitory serum factors.
Academic Article Deficient interleukin-2-activated killer cell cytotoxicity in patients with systemic lupus erythematosus.
Academic Article Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH.
Academic Article Enrichment of natural killer cells by negative selection: comparison to Percoll gradient separation method.
Academic Article Abnormal interferon modulation of natural cytotoxicity in systemic lupus erythematosus. Relation to suppressive serum factors.
Academic Article Telltale mouth flora: a clue to the diagnosis of factitious recurrent thigh abscesses.
Academic Article Antiphospholipid antibodies associated with retinal vascular disease.
Academic Article Enhancement of natural cytotoxicity by beta-endorphin.
Academic Article Characterization of E-rosette-positive Fc-receptor-bearing cells by flow cytometry.
Academic Article Perforin rapidly induces plasma membrane phospholipid flip-flop.
Academic Article Separation of natural and antibody-dependent cytotoxicity by differential reactivity of human mononuclear cell Fc receptors with IgG.
Academic Article T gamma subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis and systemic lupus erythematosus sera.
Academic Article Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins. Fluorescence perturbation and fluorescence resonance energy transfer mapping of the protease binding site in CrmA complexes with granzyme B and caspase-1.
Academic Article A case of Guillain-Barré syndrome with immunologic abnormalities.
Academic Article Lymphocytotoxic antibodies in Guillain-Barré syndrome.
Academic Article Flow cytometry and cytoadherence studies of sera from children with juvenile rheumatoid arthritis and normal controls.
Academic Article Human granzyme B is essential for DNA fragmentation of susceptible target cells.
Academic Article The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation.
Academic Article Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.
Academic Article Phytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion.
Academic Article Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin.
Academic Article Granule-mediated killing: pathways for granzyme B-initiated apoptosis.
Academic Article Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.
Academic Article Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis.
Academic Article Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.
Academic Article Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
Academic Article Right place, right time.
Academic Article Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.
Academic Article Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells.
Academic Article Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage.
Academic Article Human perforin employs different avenues to damage membranes.
Academic Article D-penicillamine-induced myasthenia gravis in rheumatoid arthritis.
Academic Article Induction of lymphokine activated killer cells in serum-free medium.
Academic Article Glomerulosclerosis in the sudden infant death syndrome.
Academic Article Effects of MACPF/CDC proteins on lipid membranes.
Academic Article Granzyme A produced by ?(9)d(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen.
Academic Article Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis.
Academic Article Membrane pore formation at protein-lipid interfaces.
Academic Article Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.
Academic Article Can foot orthoses prevent hallux valgus deformity in rheumatoid arthritis? A randomized clinical trial.
Academic Article Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.
Academic Article Granzymes A and K differentially potentiate LPS-induced cytokine response.
Academic Article Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis.
Academic Article Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.
Concept Bcl-2-Like Protein 11
Concept Caspase Inhibitors
Concept Myeloid Cell Leukemia Sequence 1 Protein
Search Criteria
  • Enkephalin
  • D Penicillamine
  • 2
  • 5